aztreonam
Drug class
Active ingredient: aztreonam
- MonobactamsATC code: J01DFSource: ATC
Allergy cross-reactivity
Class-level overall cross-reactivity (penicillin ↔ cephalosporin)
Risk level: Low
Basis: Class-wide (non-R1-matched pairs) — context group
Other active ingredients in the same group:
- amoxicillin
- ampicillin
- benzylpenicillin
- cefadroxil
- cefalexin
- cefazolin
- cefepime
- cefixime
- cefotaxime
- ceftazidime
- ceftriaxone
- cefuroxime
- flucloxacillin
- piperacillin
Notes: Class-level overall cross-reactivity between penicillins and cephalosporins is LOW in modern data (~1-2%). The R1 side chain is the true determinant. Consult a specialist.
Source: https://www.ncbi.nlm.nih.gov/books/NBK459320/Ceftazidime ↔ Aztreonam (identical R1)
Risk level: Moderate
Basis: Identical R1 side chain
Other active ingredients in the same group:
- ceftazidime
Notes: Ceftazidime has a side chain identical to aztreonam and clinical cross-reactivity has been demonstrated in vitro. Consult a specialist.
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC1291320/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Very low levels in milk; compatible.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501072/e-lactancia
Risk level: Compatible
Very low levels in milk; compatible.
Source: https://www.e-lactancia.org/breastfeeding/aztreonam/product/
Breastfeeding safety requires individual assessment; consult a physician.
Data is in part from e-lactancia.org (CC BY-NC-SA 4.0).