carbamazepine
Drug class
Active ingredient: carbamazepine
- Carboxamide derivativesATC code: N03AFSource: ATC
Allergy cross-reactivity
Aromatic AED SJS/TEN/DRESS cross-reactivity
Risk level: High
Basis: Shared aromatic ring; SCARs associated with HLA-B*15:02. Reported cross-reaction rates 30-58% (e.g. carbamazepine→phenytoin 57.6%). Numeric odds ratios not confirmed from primary source.
Other active ingredients in the same group:
- lamotrigine
- oxcarbazepine
- phenobarbital
- phenytoin
Notes: In a patient who develops SJS/TEN with one agent, avoid the others in this group. Lamotrigine cross-reacts less frequently. Consult a specialist.
Source: https://pubmed.ncbi.nlm.nih.gov/18490142/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Compatible with breastfeeding; monitor infant.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501271/
Breastfeeding safety requires individual assessment; consult a physician.