valproic acid
Drug class
Active ingredient: valproic acid
- Fatty acid derivativesATC code: N03AGSource: ATC
Allergy cross-reactivity
Non-aromatic safe alternatives
Risk level: Low
Basis: Lack of shared aromatic ring; low cross-reactivity for aromatic-AED SCARs, used as switch targets (valproate, levetiracetam, gabapentin tolerated as alternatives).
Other active ingredients in the same group:
- gabapentin
- levetiracetam
Notes: Considered safer alternatives after prior aromatic-AED hypersensitivity; consult a specialist.
Source: https://pubmed.ncbi.nlm.nih.gov/18490142/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Compatible with breastfeeding; monitor infant.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501274/
Breastfeeding safety requires individual assessment; consult a physician.