ibuprofen
Drug class
Active ingredient: ibuprofen
- Propionic acid derivativesATC code: M01AESource: ATC
Allergy cross-reactivity
Strong COX-1 inhibitors (cross-intolerance group)
Risk level: High
Basis: NSAID cross-reactivity is pharmacological not immunological: strong COX-1 inhibition triggers NERD/NECD/NIUA. A patient reacting to one strong COX-1 inhibitor is likely to react to others regardless of chemical class.
Other active ingredients in the same group:
- aspirin
- dexketoprofen
- diclofenac
- etodolac
- indomethacin
- ketoprofen
- meloxicam
- naproxen
- piroxicam
Notes: Caution: meloxicam is preferential (not fully selective) COX-2; lower but NOT absent cross-reactivity (~6.7%, effectively moderate); kept here for safety. Confirm tolerance with a specialist.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004000/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Preferred NSAID during breastfeeding; very low milk levels, short half-life.
Source: https://www.ncbi.nlm.nih.gov/books/NBK500986/
Breastfeeding safety requires individual assessment; consult a physician.