piroxicam
Drug class
Active ingredient: piroxicam
- OxicamsATC code: M01ACSource: ATC
Allergy cross-reactivity
Strong COX-1 inhibitors (cross-intolerance group)
Risk level: High
Basis: NSAID cross-reactivity is pharmacological not immunological: strong COX-1 inhibition triggers NERD/NECD/NIUA. A patient reacting to one strong COX-1 inhibitor is likely to react to others regardless of chemical class.
Other active ingredients in the same group:
- aspirin
- dexketoprofen
- diclofenac
- etodolac
- ibuprofen
- indomethacin
- ketoprofen
- meloxicam
- naproxen
Notes: Caution: meloxicam is preferential (not fully selective) COX-2; lower but NOT absent cross-reactivity (~6.7%, effectively moderate); kept here for safety. Confirm tolerance with a specialist.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004000/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Caution
Long half-life, limited data; shorter-acting alternatives preferred.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501071/
Breastfeeding safety requires individual assessment; consult a physician.