paracetamol
Drug class
Active ingredient: paracetamol
- AnilidesATC code: N02BESource: ATC
Allergy cross-reactivity
Selective COX-2 inhibitors / safe alternative
Risk level: Low
Basis: Selective COX-2 inhibitors spare COX-1 and are generally tolerated in COX-1-mediated NSAID hypersensitivity. Paracetamol is a weak COX inhibitor, likewise generally tolerated.
Other active ingredients in the same group:
- celecoxib
- etoricoxib
Notes: Generally tolerated but never absolutely safe; a minority still react (celecoxib ~10%). Confirm by a specialist.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936045/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Long history of safe use; low milk levels. First-choice analgesic/antipyretic.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501194/
Breastfeeding safety requires individual assessment; consult a physician.