articaine
Drug class
Active ingredient: articaine
- AmidesATC code: N01BBSource: ATC
Allergy cross-reactivity
Amide local anesthetics
Risk level: Low
Basis: Amide local anesthetics are not metabolized to PABA. Cross-reactivity between amide agents is rare, and there is NO cross-reactivity between ester and amide groups.
Other active ingredients in the same group:
- bupivacaine
- lidocaine
- mepivacaine
- prilocaine
Notes: Cross-reactivity among amides is rare and no ester-amide cross-reactivity occurs. True IgE-mediated LA allergy is rare (<1%); most reactions are caused by methylparaben. Do not give a binary safe/allergic answer; consult a specialist.
Source: https://www.ncbi.nlm.nih.gov/books/NBK430894/
Cross-reactivity risk is not definitive; consult an allergy/infectious disease specialist.
Breastfeeding
LactMed
Risk level: Compatible
Short half-life, minimal milk transfer; compatible.
Source: https://www.ncbi.nlm.nih.gov/books/NBK501746/
Breastfeeding safety requires individual assessment; consult a physician.